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Papers published in 2004
1. Chan TL, Chan YW, Ho JW, Chan C, Chan AS, Chan E, Lam PW, Tse CW, Lee KC, Lau CW, Gwi E, Leung SY, Yuen ST. MSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary nonpolyposis colorectal cancer in the southern Chinese population. Am J Hum Genet 2004 May;74(5):1035-42. Epub 2004 March 23.
Abstracts presented in meetings 2004
1. Guo DL, Yuen ST, Ho JWC, Chan ASY, Chen X and Leung SY. PLA2G2A expression and its clinical significance in colorectal tumour. 95th Annual Meeting of American Association for Cancer Research, April 2004, Orlando, Florida, USA.
2. Chan TL, Wong CW, Chan AS, Chan ASY, Guo D, Ho JWC, Yuen ST and Leung SY. BRAF and KRAS mutations in mismatch repair deficient colorectal cancer. 95th Annual Meeting of American Association for Cancer Research, April 2004, Orlando, Florida, USA.
Invited talks in local and international conferences in 2004
1. Dr. Judy Ho
“Epidemiology and screening of colorectal cancer”
Invited talk presented at “Care for the Ostomates: Transdisciplinary Collaboration” Symposium, 25th Anniversary of the Hong Kong Stoma Association, (20th November 2004), Hong Kong.
2. Drs. S.Y. Leung and S.T. Yuen
“Microsatellite instability in colon cancer – causes and molecular pathways of tumour development”
Invited talk presented at 6th jointed annual scientific meeting of the Hong Kong Society of Gastroenterology, (9th October 2004), Hong Kong.
3. Drs. S.Y. Leung and S.T. Yuen
“Advances in molecular genetics in colorectal cancer”
Invited talk presented at Asia Pacific Digestive Week, (7th October 2004), Beijing, China.
4. Dr. Judy Ho
“Early-onset colorectal cancer in Hong Kong Chinese: epidemiology, genetic and clinical studies”
Invited talk at Research Seminar, Centre for Academic Surgery, Royal London Hospital, (20th September 2004), London, United Kingdom.
5. Drs. S.Y. Leung and S.T. Yuen
“Advances in molecular genetics in colorectal cancer”
Invited talk presented at Hong Kong Sanatorium & Hospital and Stanford University Medical Centre Joint Teleconference Symposium entitled “Management of G.I. Malignancy”, (18th September 2004), Hong Kong.
6. Dr. Judy Ho
“Screening for colon cancer, are we ready in Hong Kong?”
Invited talk presented at Alimentary Disease Weekend, The University of Hong Kong, (18th to 19th September 2004), Hong Kong.
7. Dr. Judy Ho
“Trend and management of FAP and hereditary colorectal cancer in Hong Kong”
Invited talk at Annual Scientific Meeting of the Hong Kong Enterostomal Therapists Association, (17th April 2004), Hong Kong.
Papers published in 2003
1. Ho SM, Ho JW, Chan CL, Kwan K and Tsui YK. Decisional consideration of hereditary colon cancer genetic test results among Hong Kong Chinese adults. Cancer Epidemiol Biomarkers Prev. 2003 May;12(5):426-32.
2. Chan TL, Zhao W, Cancer Genome Project, Leung SY and Yuen ST. BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas. Cancer Res. 2003 Aug 15;63(16):4878-81.
Abstracts presented in meetings 2003
1. Chan TL, Yuen ST, Davies H, Ho JW, Bignell GR, Cox C, Stephens P, Edkins S, Tsui WW, Chan AS, Futreal PA, Stratton MR, Wooster R and Leung SY. Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. 94th Annual Meeting of American Association for Cancer Research, April 2003, Toronto, Canada.
2. Ho J, Ho S, Chan C, Yuen ST, Chan E, Siu V. Psychological profile of hereditary colorectal cancer genetic screening test recipients in Hong Kong: results of the first 88 participants. Familial Cancer 2003: research and practice, Couran Cove, Australia 3-6 September 2003.
Papers published in 2002
1. Yuen ST, Chan TL, Ho JW, Chan AS, Chung LP, Lam PW, Tse CW, Wylie AH, Leung SY. Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers. Oncogene 2002 Oct 24; 21(49):7585-7592
2. Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA. Mutations of the BRAF gene in human cancer. Nature 2002 Jun; 417(6892):949-954
3. Yuen ST, Davies H, Chan TL, Ho JW, Bignell GR, Cox C, Stephens P, Edkins S, Tsui WW, Chan AS, Futreal PA, Stratton MR, Wooster R, Leung SY. Similarity of the Phenotypic Patterns Associated with BRAF and KRAS Mutations in Colorectal Neoplasia. Cancer Res 2002 Nov15; 62(22):6451-6455
4. Ho JW, Chu KM, Tse CW, Yuen ST. Phenotype and management of patients with familial adenomatous polyposis in Hong Kong: perspective of the Hereditary Gastrointestinal Cancer Registry. Hong Kong Med J 2002 Oct; 8(5):342-347
5. Tsui JHL, Ho JWC. COX-2 inhibitors and colorectal cancer chemoprevention. Ann Coll Surg HK 2002; 6:31-35
Abstracts and talks presented in 2002
1. Leung SY, Chan TL, Ho JWC, Chan ASY and Yuen ST. A founder mutation of hMSH2 in Chinese with early onset colorectal cancer. 93rd Annual Meeting of American Association for Cancer Research, April 2002, San Francisco, USA.
2. Leung SY and Yuen ST. Colorectal Cancer – Genetic Diagnosis and Screening. Inaugural Symposium: 21st Century Health Care in Hong Kong: A New Era. Faculty of Medicine, The University of Hong Kong, June 2002, Hong Kong.
3. Yuen ST. Molecular genetics of colorectal cancer. 18th World Congress of Digestive Surgery & 9th Hong Kong International Cancer Congress, 8 – 11 December 2002.
4. Ho JWC. The Hereditary Gastrointestinal Cancer Registry of Queen Mary Hospital. 18th World Congress of Digestive Surgery & 9th Hong Kong International Cancer Congress, 8 – 11 December 2002.
5. Ho JWC, Ng KC, Chan E, Yuen ST. Clinical predictors of MSI and MMR gene mutation in colorectal cancers. 18th World Congress of Digestive Surgery & 9th Hong Kong International Cancer Congress, 8 – 11 December 2002.
6. Ho JWC, Ho S, Chan C. Decisional consideration of hereditary colon cancer genetic test results among Hong Kong Chinese adults. 18th World Congress of Digestive Surgery & 9th Hong Kong International Cancer Congress, 8 – 11 December 2002.
7. Chan CLW, Ho SMY, Ho J, Yee KKW. The continuation of a family curse? A qualitative study of the illness experience of patients suffering from hereditary colon cancer. 18th World Congress of Digestive Surgery & 9th Hong Kong International Cancer Congress, 8 – 11 December 2002.
Papers published in 2001
1. Yuen ST. Colorectal cancer - Hereditary cancer syndromes and significance of genetic diagnosis. Hong Kong Society of Gastroenterology Newsletter. 2001 Jan; p.6.
2. Chan TL, Yuen ST, Ho JWC, Chan ASY, Kwan KYM, Chung LP, Lam PWY, Tse CW and Leung SY. A novel germline 1.8-kb deletion of hMLH1 mimicking alternative splicing: A founder mutation in Chinese population. Oncogene 2001 May 24;20(23):2976-81
3. Chan TL, Curtis LC, Leung SY, Farrington SM, Ho JW, Chan AS, Lam PW, Tse CW, Dunlop MG, Wyllie AH, Yuen ST. Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes. Oncogene. 2001 Aug 9;20(35):4871-6”
4. Andreyev HJ, Norman AR, Cunningham D, Oates J, Dix BR, Iacopetta BJ, Young J, Walsh T, Ward R, Hawkins N, Beranek M, Jandik P, Benamouzig R, Jullian E, Laurent-Puig P, Olschwang S, Muller O, Hoffmann I, Rabes HM, Zietz C, Troungos C, Valavanis C, Yuen ST, Ho JW, et al. Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer. 2001 Sep;85(5):692-6”.
Abstracts and talks presented in 2001
1. Leung SY, Chan TL, Ho JWC, Chan ASY, Chung LP, Kwan YM and Yuen ST. Immunohistochemical study is a good predictor for microsatellite instability and MMR gene inactivation. 92nd Annual Meeting of American Association for Cancer Research, 24 - 28 March 2001, New Orleans, USA
2. Ho JWC, Yuen ST, Kwan STM, Chung LP. APC gene mutation: genotype-phenotype correlation in Hong Kong Chinese Polyposis families. 3rd Joint Meeting of Leeds Castle Polyposis Group and ICG-HNPCC, Venice 26-28 April 2001
3. Leung SY, Chan TL, Ho JWC, Chan ASY, Chan YW, Kwan KYM, Yuen ST. hMSH6 mutation and protein expression in colorectal cancers with normal hMSH2 and hMLH1. 3rd Joint Meeting of LCPG and ICG-HNPCC, Venice 26-28 April 2001.
4. Yuen ST, Chan TL, Ho JWC and Leung SY. Microsatellite instability and mismatch repair genes in human cancers. UICC Familial Cancer Project and International Oncology Conference, 2 - 4 May 2001, Beijing, People's Republic of China.
5. Yuen ST. Genetic alterations in colorectal carcinoma. Histopathology Course 2001, The International Academy of Pathology (IAP), Hong Kong Division, Prince of Wales Hospital, Hong Kong, 9th June 2001.
6. Chan TL, Yuen ST, Ho JWC, Chan ASY, Kwan KYM, Chung LP, Lam PWY, Tse CW and Leung SY. A novel germline 1.8-kb deletion of hMLH1 mimicking alternative splicing: A founder mutation in Chinese population. AACR International Conference Seoul 2001 - Molecular Mechanisms Gastrointestinal Cancer Development and Its Clinical Applications, Seoul 10 - 14 September 2001.
7. Chan TL, Curtis LC, Leung SY, Farrington SM, Ho JW, Chan AS, Lam PW, Tse CW, Dunlop MG, Wyllie AH, Yuen ST. Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes. 3rd Joint Scientific Meeting of the Hong Kong Society of Gastroenterology, Hong Kong Society of Digestive Endoscopy and Hong Kong Society for Coloproctology. 21 - 22 September 2001.
8. Yuen ST. Genetic screening for colorectal carcinoma. 3rd Joint Scientific Meeting of the Hong Kong Society of Gastroenterology, Hong Kong Society of Digestive Endoscopy and Hong Kong Society for Coloproctology, Hong Kong. 21 - 22 September 2001.
9. Yuen ST. Molecular biology of colorectal cancer. OMGE (World Organisation of Gastroenterology) Symposium on Gastrointestinal Cancer, 2nd Congress of Digestive Disease Week-China, Shanghai, 6th - 9th November 2001.
List of Previous Publications (up to December 2000)
Original articles
1. Yuen ST, Chung LP, Leung SY, Luk ISC, Chan SY, Ho JCI, Ho JWC, Wyllie AH.
Colorectal carcinoma in Hong Kong : epidemiology and genetic mutation. Br J Cancer 1997; 76(12): 1610-6.
2. Yuen ST, Chan TL, Chung LP, Ho JWC, Chan SY, Ho JCY, Leung SY.
Microsatellite instability and mismatch repair gene mutations are common in young colorectal cancer patients in Hong Kong. HKMJ (Supplement) 1998; 4(4) : 9.2
3. Ho JWC, Kwan KYM, Yuen ST, Chung LP. Colonoscopic surveillance and screening for familial colorectal cancer : experience of a regional registry. HKMJ (Supplement) 1998; 4(4) : 10.7
4. Ho JWC, Yuen ST, Chung LP, Kwan KYM. Genetic-guided screening programme for familial adenomatous polyposis : result of a regional registry. HKMJ (Supplement) 1998; 4(4) : 10.9
5. Yuen ST, Chung LP, Ho J, Chan TL, So KC, Leung SY. Genetic diagnosis for hereditary colorectal cancer syndromes. Proceedings of First Hong Kong Medical Genetics Conference. Edited by Stephen Lam, Mary Tang, Ivan Lo and WK Chan. The Hong Kong Society of Medical Genetics, Hong Kong. 1998: 71-75.
6. Leung SY, Chan TL, Chung LP, Chan ASY, Fan YW, Hung KN, Kwong WK, Ho JWC, Yuen ST. Microsatellite instability and mutation of DNA mismatch repair genes in gliomas. Am J Pathol 1998; 153(4) : 1181 – 1188
7. Chan TL, Yuen ST, Chung LP, Ho JWC, Kwan KYM, Fan YW, Chan ASY, Leung SY. Germline hMSH2 and differential somatic mutations in patients with Turcot’s syndrome. Genes Chromosomes & Cancer 1999; 25: 75-81.
8. Chan TL, Yuen ST, Chung LP, Ho JWC, Kwan KYM, Chan ASY, Ho JCY, Leung SY, Wyllie AH. Frequent microsatellite instability and mismatch repair gene mutations in young Chinese patients with colorectal cancer. J Natl Cancer Inst 1999; Jul 21; 91(14): 1221-1226.
9. Ho JWC, Yuen ST, Chung LP, So HC, Kwan KYM. The role of sulindac in familial adenomatous polyposis patients with ileal pouch polyposis. Aust NZ J Surg 1999; 69: 756-758.
10. Ho JWC, Yuen ST, Chung LP, Kwan KYM, Chan TL, Leung SY, Chan ASY, Tse CW, Lam PWY and Luk ISC. Distinct clinical features associated with microsatellite instability in colorectal cancers of young patients. Int J Cancer. 2000 Jul 20;89(4):356-60.
11. Leung SY, Yuen ST, Chan TL, Chan ASY, Ho JWC, Fan YW, Hung KN, Chung LP and Wyllie AH. Chromosomal instability and p53 inactivation are required for genesis of glioblastoma but not for colorectal cancer in patients with germline mismatch repair gene mutation. Oncogene. 2000 Aug 17;19(35):4079-83.
12. Desai DC, Lockman JC, Chadwick RB, Gao X, Percesepe A, Evans GR, Miyaki M, Yuen ST, Radice P, Maher ER, Wright FA and de la Chapelle A. Recurrent germline mutation in MSH2 arises frequently de novo. J Med Genet. 2000 Sep;37(9):646-52.
13. Ho JWC and Yuen ST. Screening of hereditary colorectal cancer syndromes (review). Asian J Surg. 2000 Oct;23(4):332-343.
Abstracts
1. Yuen ST, Chung LP, Ho JWC, So KC, Chan TL, Leung SY. Genetic screening for Familial Adenomatous Polyposis. 3rd Hong Kong International Cancer Congress 13-16 November, 1996.
2. Chan TL, Yuen ST, Chung LP, Ho J, Leung SY, Chan LC. Replication errors (RER) and mismatch repair (MMR) gene mutations in young colorectal carcinoma patients in Hong Kong Chinese. Genetics of Human Cancer: Pathogenesis & Diagnosis, Keystone, CO, USA, January 27 – February 2, 1997.
3. Yuen ST, Chung LP, Ho J, Chan TL, So KC, Leung SY. Genetic diagnosis for hereditary colorectal cancer syndromes. Proceedings of the First Hong Kong Medical Genetics Conference, Hong Kong, 25-27 January 1997.
4. Yuen ST, Chung LP, Chan ASY, Ho J, Ho JWC, Wyllie AH. Colorectal carcinoma of Hong Kong : Epidemiology and genetic mutations. Proceedings of the 88th Annual Meeting of the American Association for Cancer Research, San Diego USA 12-16 April, 1997.
5. Ho JWC, Kwan KYM, Yuen ST. Screening for familial colorectal cancer : preliminary result from a regional registry. 4th Hong Kong International Cancer Congress and 14th Asian Pacific Cancer Conference, Hong Kong, November 1997.
6. Chung LP, Yuen ST, Ho JWC, Kwan K, So KC, Chan TL. Detection of germline APC gene mutation in Familial Adenomatous Polyposis patients in Hong Kong. 4th Hong Kong International Cancer Congress and 14th Asian Pacific Cancer Conference, Hong Kong, November 1997.
7. Chan TL, Yuen ST, Chung LP, Ho JWC, Kwan K. Microsatellite analysis and mismatch repair gene mutation in colorectal cancer patients in Hong Kong. 4th Hong Kong International Cancer Congress and 14th Asian Pacific Cancer Conference, Hong Kong, November 1997. (Winner of the Young Investigator’s Award)
8. Yuen ST, Chan TL, Leung SY, Ho JWC, Kwan KYM, Chung LP.
Microsatellite instability and mismatch repair gene mutation in colorectal cancer patients in Hong Kong. Proceedings of the 89th Annual Meeting of the American Association for Cancer Research, New Orleans, 28 March – 1 April 1998.
9. Ho JWC, Yuen ST, Chung LP, Kwan KYM. Genetic-guided screening programme for familial adenomatous polyposis : result of a regional registry. First International Congress, Hong Kong Academy of Medicine, November 1998
10. Ho JWC, Kwan KYM, Yuen ST, Chung LP. Colonoscopic surveillance and screening for familial colorectal cancer : experience of a regional registry. First International Congress, Hong Kong Academy of Medicine, November 1998.
11. Yuen ST, Chan TL, Chung LP, Ho JWC, Chan SY, Ho JCY, Leung SY. Microsatellite instability and mismatch repair gene mutations are common in young colorectal cancer patients in Hong Kong. First International Congress, Hong Kong Academy of Medicine, November 1998.
12. Yuen ST, Chan TL, Chung LP, Ho JWC, Chan SY, Ho JCY, Leung SY. Microsatellite instability and mismatch repair gene mutations are common in young colorectal cancer patients in Hong Kong. First International Congress, Hong Kong Academy of Medicine, November 1998
13. Yuen ST. Molecular genetics in colorectal cancer. 5th Hong Kong International Cancer Congress, November 1998, Hong Kong
14. Chan TL, Leung SY, Chung LP, Chan ASY, Fan FW, Hung KN, Kwong WK, Ho JWC, Yuen ST. Microsatellite instability and mutation of DNA mismatch repair genes in gliomas. 5th Hong Kong International Cancer Congress, 8-11 November 1998 (Winner of the Young Investigator’s Award)
15. Chan TL, Yuen ST, Ho JWC, Chung LP, Kwan KYM, YM Fan, Chan ASY, Leung SY. Germline hMSH2 and differential somatic mutations in patients with Turcot’s syndrome. 2nd Joint Meeting, LCPG and ICG-HNPCC, Melbourne & Lorne, Australia, March, 1999.
16. Chan TL, Yuen ST, Chung LP, Ho JWC, Fan YW, Chan ASY, Leung SY. Germline hMSH2 and differential somatic mutations in patients with Turcot’s syndrome. 90th Annual Meeting of American Association for Cancer Research, Philadelphia, PA, April 1999.
17. Chan TL, Curtis LJ, Leung SY, Farrington SM, Chan ASY, Ho JWC, Lam PWY, Tse CW, Dunlop MG, Yuen ST and Wyllie AH. Molecular genetics of colorectal cancer in young patients from Hong Kong and Scotland. 91st Annual Meeting of American Association for Cancer Research, 1 - 5 April 2000, San Francisco, USA.
18. Yuen ST, Leung SY, Chan TL, Ho JWC and Chung LP. Microsatellite instability and mismatch repair genes in human cancers. First International Congress of the Romanian Society for Cell Biology, 7 - 10 June 2000, Iasi, Romania.
19. Ho JWC, Yuen ST, Chung LP, Kwan YM, Chan TL, Leung SY, Chan ASY, Tse CW, Lam PWY and Luk ISC. Distinct clinical features associated with microsatellite instability in colorectal cancers of young patients. 12th ICG-HNPCC Meeting, 20 - 24th September 2000, Israel.
20. Leung SY, Chan TL, Ho JWC, Chan ASY, Chung LP, Kwan YM and Yuen ST. Immunohistochemical study is a good predictor for microsatellite instability and MMR gene inactivation. 12th ICG-HNPCC Meeting, 20 - 24th September, 2000, Israel.
21. Yuen ST. Hereditary and Early-Onset Colorectal Cancer: Genetic Diagnosis and implication. 2nd Annual Scientific Symposium of the Centre of Alimentary Research and Education (CARE), 10th December 2000, Hong Kong.
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